TY - JOUR ID - 138153 TI - The Relationship between Third Ventricle Diameter, Motor Disability , and Cognitive Decline in Patients with Multiple Sclerosis JO - Journal of Iranian Medical Council JA - JIMC LA - en SN - 2645-338X AU - Kamali, Maede AU - Joghataei, Mohammad Taghi AU - Almasi-Dooghaee, Mostafa AU - Babaie, Mahla AU - Esmaeili, Sara AU - Nouri-Shirazi, Shabnam AU - Abbasi, Mohammad Hossein AU - Abdi, Yasaman AU - Mirzaasgari, Zahra AD - Department of Neurology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran AD - Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran AD - Student Research Committee, Iran University of Medical Sciences, Tehran, Iran AD - Institute for Cognitive Science Studies, Pardis, Tehran, Iran Y1 - 2021 PY - 2021 VL - 4 IS - 3 SP - 153 EP - 158 KW - Cognitive dysfunction KW - Humans KW - Motor disorders KW - Multiple Sclerosis KW - neuroimaging KW - Third ventricle DO - http://dx.doi.org/10.18502/jimc.v4i3.7216 N2 - Background: Multiple Sclerosis (MS) causes brain atrophy at the early stages of the disease which leads to progressive motor and cognitive dysfunction. Brain atrophy can be diagnosed indirectly by measuring the Third Ventricle Diameter (TVD) using Trans Cranial Sonography (TCS). The purpose of the current study was evaluation of TVD in MS patients using TCS to examine its possible correlation with cognitive dysfunction and Expanded Disability Status Scale (EDSS).Methods: Seventy-four patients with a definite diagnosis of MS were enrolled in this study. Transverse diameter of the third ventricle was measured using TCS. All patients were assessed by neurological examination and the level of disability was measured via EDSS. The cognitive performance was assessed by the Brief  International Cognitive Assessment for Multiple Sclerosis (BICAMS). Pearson’s correlation was performed to evaluate possible correlations and p-value<0.05 was considered statistically significant. Results: From the total 74 individuals, 58.1% were diagnosed with Relapse-Remitting MS (RRMS) (n=43) and 43.9% with Secondary-Progressive MS (SPMS) (n=31). The mean EDSS score was 1.81±1.38 (Range of 0-10). The mean TVD was 5.61±1.82 cm which had no statistical correlation with the EDSS score, but it was significantly wider in group with EDSS score>3 when compared to the group with EDSS score≤3 (p-value=0.0001). The mean BICAMS score was 0.65±0.57 and there was no statistical correlation between BICAMS score and TVD. Conclusion: Measuring the diameter of the third ventricle using TCS appears to be an appropriate method to diagnose brain atrophy and is associated with cognitive dysfunction in the process of MS. Our data emphasized no association between the diameter of the third ventricle and cognitive dysfunction. UR - http://www.jimc.ir/article_138153.html L1 - http://www.jimc.ir/article_138153_5e5b1daff18e82458e1e767a042c1e9a.pdf ER -