TY - JOUR ID - 143976 TI - Risk Stratification for In-Hospital Mortality in Adult Patients with COVID-19 JO - Journal of Iranian Medical Council JA - JIMC LA - en SN - 2645-338X AU - Pazoki, Marzieh AU - Payandemehr, Pooya AU - Montazeri, Mahnaz AU - Kafan, Samira AU - Sheikhvatan, Mehrdad AU - Sotoodehnia, Mehran AU - Salimzadeh, Ahmad AU - Ebrahimi, Mehdi AU - Najafi, Atabak AU - Shariat Moharari, Reza AU - Khajavi, Mohammad Reza AU - Talebpour, Mohammad AU - Ashraf, Haleh AU - Aghamir, Seyed Mohammad Kazem AU - Karbalai Saleh, Shahrokh AU - Shakouri Rad, Ali AU - Moradi Tabriz, Hedieh AU - Najmeddin, Farhad AU - Arya, Pantea AU - Peirovi, Niloufar AU - Kazemian, Sina AU - Kashani, Mehdi AU - Babaei, Sorya AU - Hadadi, Azar AD - Department of Pulmonary Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Emergency Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Research Center For Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran AD - Heidelberg Medical Hospital, Heidelberg, Germany AD - Rheumatology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Endocrinology Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Anesthesiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Urology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Cardiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Radiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Pathology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Psychology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran AD - Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Y1 - 2021 PY - 2021 VL - 4 IS - 4 SP - 322 EP - 334 KW - COVID-19 KW - mortality KW - risk factors KW - SARS-CoV-2 DO - http://dx.doi.org/10.18502/jimc.v4i4.8480 N2 - AbstractBackground:  Since the outbreak of coronavirus 2019 (COVID-19), identifying risk factors associated with in-hospital mortality has been a global priority. In this study, the purpose was to evaluate the clinical, laboratory, and radiological characteristics of hospitalized patients with COVID-19 to develop a predictive model and scoring system for in-hospital mortality.Methods: In this retrospective cohort study, 611 adult patients with COVID-19, admitted to Sina hospital were enrolled and followed up.Results: Out of the total number of 611 patients, 104 patients (17%) deceased during hospitalization, including 75 (12.2%) deaths in ICU and 29 (4.7%) deaths in the wards. After multivariate logistic regression analysis, several characteristics including age >55 years, previous history of malignancy, history of cerebrovascular accident, tachypnea on admission, CRP>54 on admission, D-dimer>1300, and bilateral pulmonary consolidation on chest Computed Tomography (CT) were shown to be the main determinants for stratifying the risk for in-hospital death. The factors were finally considered for introducing a new predictive scoring system for COVID-19 related death. Conclusion: In-hospital mortality rate in patients with COVID-19 is estimated to be 17%. A new scoring system for predicting in-hospital mortality in such patients was structured based on determinant factors of advanced age, history of malignancy, cerebrovascular accident, tachypnea, raised CRP, raised D-dimer on admission, and bilateral pulmonary consolidation on chest CT scan. UR - http://www.jimc.ir/article_143976.html L1 - http://www.jimc.ir/article_143976_0a12140c673dae16a0b963cad012cc3f.pdf ER -