Effects of Alcohol on Pulmonary Function in a Healthy Population

Authors

1 Air Pollution Research Center, Iran University of Medical Sciences, Tehran, Iran

2 Department of Nutrition, Faculty of Paramedical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3 Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract

Background: The lung can be the target of the harmful effects of alcohol, and to date, data on this matter are insufficient. The aim of this study was to evaluate the effects of alcohol on airway resistance in healthy individuals.
Methods: This was a cross sectional study conducted with 24 cases and 26 controls. The cases were alcohol consumers of more than 4 years with no comorbidity or disease. Pulmonary function tests and body plethysmography were performed to determine FEV1, FVC, TLC, RV and FEV1/FVC and participant’s response to bronchodilators. The amount of alcohol consumption and its duration were measured by visual scales and portion size album.
Results: The mean values of FVC, FEV1, TLC, and RV did not differ significantly between the two groups. In the case group, FEV1 and age were significantly correlated (r=-0.460, p=0.049). There was an insignificant correlation value of -0.06 (p=0.752) between FEV1 and age in the control group. Also, there was no significant correlation between age and FVC, TLC or RV in both groups.
Conclusion: Overall, there was a strong, negative correlation between FEV1 and age in the case group of this study, and it appears that alcohol slightly enhanced the effect of age on pulmonary function tests.



Keywords


1. Grant BF. Prevalence and correlates of alcohol use and DSM-IV alcohol dependence in the United States: results of the National Longitudinal Alcohol Epidemiologic Survey. J Stud Alcohol 1997;58(5):464-73.
2. Oldenburg PJ, Wyatt TA, Factor PH, Sisson JH. Alcohol feeding blocks methacholine-induced airway responsiveness in mice. Am J Physiol Lung Cell Mol Physiol 2009;296(1):L109-L14.
3. Sisson JH. Alcohol and airways function in health and disease. Alcohol 2007;41(5):293-307.
4. Matsuse H, Shimoda T, Fukushima C, Mitsuta K, Kawano T, Tomari S-y, et al. Screening for acetaldehyde dehydrogenase 2 genotype in alcohol-induced asthma by using the ethanol patch test. J Allergy Clin Immunol 2001;108(5):715-9.
5. Zureik M, Liard R, Kauffmann F, Henry C, Neukirch F. Alcohol consumption, gamma‐glutamyl transpeptidase (GGT), and pulmonary function: A cross‐sectional and longitudinal study in working men. Alcohol Clin Exp Res 1996;20(9):1507-11.
6. Catharine Ross A. Modern Nutrition in Health and Disease, eds. Baltimore: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2014. 1616 p.
7. Eckert DJ, Elgar NJ, McEvoy RD, Catcheside PG. Alcohol alters sensory processing to respiratory stimuli in healthy men and women during wakefulness. Sleep 2010;33(10):1389-95.
8. Berkowitz DM, Danai PA, Eaton S, Moss M, Martin GS. Alcohol abuse enhances pulmonary edema in acute respiratory distress syndrome. Alcohol Clin Exp Res 2009;33(10):1690-6.
9. Samokhvalov A, Irving H, Rehm J. Alcohol consumption as a risk factor for pneumonia: a systematic review and meta-analysis. Epidemiol Infect 2010;138(12):1789-95.
10. Salter H. Treatment of the asthmatic paroxysm by full doses of alcohol. Boston Med Surg J 1863;69(19):379-83.
11. Herxheimer H, Stresemann E. Ethanol and lung function in bronchial asthma. Arch Int Pharmacodyn Ther 1963;144:310-4.
12. Cuddy R, Li G. The role of alcohol in asthma: a review of clinical and experimental studies. The Am J Emerg Med 2001;19(6):501-3.
13. Frantz S, Wollmer P, Dencker M, Engström G, Nihlén U. Associations between lung function and alcohol consumption Assessed by both a questionnaire and a blood marker. Respir Med 2014;108(1):114-21.
14. Kerstjens H, Rijcken B, Schouten JP, Postma DS. Decline of FEV1 by age and smoking status: facts, figures, and fallacies. Thorax 1997;52(9):820-7.
15. Sharma G, Goodwin J. Effect of aging on respiratory system physiology and immunology. Clin Interv Aging 2006;1(3):253-60.
16. Tashkin DP. Variations in FEV1 decline over time in chronic obstructive pulmonary disease and its implications. Current Opinion in Pulmonary Medicine 2013;19(2):116-24.
17. Siu ST, Iribarren C, Udaltsova N, Ranga R, Chen JL, Klatsky AL. Alcohol consumption and lung function. Chest 2007;132(4):614B.