@article { author = {Rashidinia, Ali and Bozorgi, Ali and Abdollahi, Alireza and Naserghandi, Alvand and Ataeinia, Bahar and Allameh, Farshad}, title = {Celiac Disease Seropositivity in Dilated Cardiomyopathy Patients and Correlation with Ejection Fraction}, journal = {Journal of Iranian Medical Council}, volume = {5}, number = {1}, pages = {140-146}, year = {2022}, publisher = {Iran Medical Council}, issn = {2645-338X}, eissn = {2645-3398}, doi = {http://dx.doi.org/10.18502/jimc.v5i1.9582}, abstract = {Background: Recent evidence suggests a connection between celiac disease and dilated cardiomyopathy. Herein, we serologically screened for celiac in dilated cardiomyopathy patients and investigated its correlation with ejection fraction.Methods: We selected 123 cardiomyopathy patients. Patients were screened for celiac, using anti-tissue transglutaminase (ATA), anti-gliadin (AGA), and anti-endomysial (EMA) immunoglobulin type A (IgA) antibodies. Total IgA levels were also measured. Results: Of 123 patients, 3 were EMA positive (2.4%), 4 were AGA positive (3.3%) and 5 were ATA positive (4.1%). EMA positive patients had significantly lower EF values compared to EMA negative patients (35±5 vs. 46.52±9.21, p-value: 0.034). Similar results were observed for AGA (32.5±14.34 vs. 46.7±8.8, p-value: 0.002), but not for either ATA positivity (40±10 vs. 46.5±9.21, p-value:  0.126) or IgA deficiency (50±5 vs. 46.14±9.37, p-value:  0.480). No significant difference was observed in the age and gender of seropositive patients compared to seronegative.Conclusion: We observed a higher prevalence of celiac seropositivity among dilated cardiomyopathy patients compared to the general population. EMA and AGA positive patients had significantly lower ejection fractions compared to their negative counterparts.}, keywords = {celiac disease,dilated cardiomyopathy,Ejection fraction,Serology}, url = {http://www.jimc.ir/article_151481.html}, eprint = {http://www.jimc.ir/article_151481_957887249aed71d20b900be15ed0a959.pdf} }