Iran Medical Council Journal of Iranian Medical Council 2645-338X 4 4 2021 10 01 The Role of Lymph Node Ratio in Predicting Survival in Patients with Esophageal Squamous Cell Carcinoma 296 302 143968 http://dx.doi.org/10.18502/jimc.v4i4.8477 EN Abolfazl Salari Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran Elnaz Saeedi Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran Maryam Hadji Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran Amirmohsen Jalaeefar Department of Surgery, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran 0000-0002-9882-7828 Kazem Zendehdel Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran 0000-0002-0269-4945 Mohammad Shirkhoda Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran Journal Article 2021 05 21 Abstract <br />Background: This study aimed to evaluate the role of lymph node ratio (LNR) in the prediction of Overal Survival (OS) of patients with Esophageal Squamous Cell Carcinoma (ESCC).<br />Methods: Patients with ESCC who underwent radical esophagectomy and radical lymph node dissection were entered into the study. The survival rate of patients was determined using the Kaplan–Meier estimator. Also, the effect of LNR and other variables on the OS of patients was assessed applying COX proportional hazards regression model. Based on its mean, LNR was divided into two groups of ≤0.25 and >0.25.<br />Results: In total, 116 patients were entered into the study. The univariate and multivariate analyses showed that LNR was an independent prognostic factor for the prediction of the OS of patients with ESCC. An increase of LNR more than 0.25 led to an increase in the mortality risk by 1.57 times. Also, the five-year survival of patients was 26% with LNR≤0.25 and 5% with LNR>0.25. <br />Conclusion: LNR can be used as an independent prognostic factor in determining and predicting the OS of patients with ESCC. There was a relationship between the increase of this factor and the worsening of patients’ OS.<br /><br /> https://www.jimc.ir/article_143968_13ab242d6e7c8118060135f95bcd562f.pdf