Iran Medical Council Journal of Iranian Medical Council 2645-338X 6 2 2023 04 01 Effect of Insulin Therapy on Traumatic Patients: A Scoping Review 184 206 168746 10.18502/jimc.v6i2.12229 EN Mehdi Harorani Department of Nursing, Shazand School of Nursing, Arak University of Medical Sciences, Arak, Iran Behnam Masmouei Department of Nursing, School of Nursing Hazrat Zahra (P.B.U.H) Abadeh, Shiraz University of Medical Sciences, Shiraz, Iran. Ali Zarei Department of Physiology, Estahban School of Paramedical Sciences, School of Nursing Hazrat Zahra (P.B.U.H) Abadeh, Shiraz University Of Medical Sciences, Shiraz, Iran 0000-0002-2405-691X Fereidoun Jahangiri Department of Nursing, School of Nursing Hazrat Zahra (P.B.U.H) Abadeh, Shiraz University of Medical Sciences, Shiraz, Iran , Department of Epidemiology and Biostatistics, Kerman University of Medical Sciences, Kerman, Iran Mohammad Rafi Bazrafshan Department of Nursing, School of Nursing, Larestan University of Medical Sciences, Larestan, Iran Zahra Karimi Imam Khomeini Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Mehran Akbari Department of Nursing, School of Nursing, Khomein University of Medical Sciences, Khomein, Iran 0000-0002-1699-1051 Journal Article 2022 07 23 <strong>Background:</strong> Trauma is one of the most important causes of death in. Therefore, proper management and treatment of these patients can be very beneficial. Therefore, the aim of this literature was to investigate the extent, scope and nature of researches on the effect of insulin therapy on the treatment efficacy of traumatic patients.<br><strong>Methods:</strong> This study is a scoping review of research that was conducted by searching in Scopus, PubMed, Embase and ScienceDirect databases with keywords related to insulin therapy and trauma. In this study, all reports with human and animals as well as cohort and clinical trial studies were reviewed.<br><strong>Results:</strong> Of the 4365 studies, 73 studies met the inclusion criteria and were evaluated, most studies examining the effect of insulin on traumatic brain injury and immune system and the fewest were in trunk trauma patients, especially chest trauma. The findings of this study showed the effect of insulin therapy on decreasing levels of IL-6, IL-8, IL-10 and TNF-α thus decreasing the inflammatory response in trauma patients. Insulin therapy can reduce the risk of infection in patients with trauma and burns thereby reducing the number of days spent in intensive care units and dependence on ventilation. <br><strong>Conclusion:</strong> Insulin therapy can be useful in treating trauma patients but increases the rate of hypoglycemic episodes that require careful monitoring of patients’ blood glucose which can have a negative impact on treatment outcomes. https://www.jimc.ir/article_168746_bc520002c036c299687de5dd1055e65a.pdf