Iran Medical Council Journal of Iranian Medical Council 2645-338X 9 3 2026 07 01 Prediction of Anxiety and Depression Based on Perceived Social Support and Socioeconomic Status in Cystic Fibrosis Patients: A Study in Tehran, Iran 736 744 245110 10.18502/jimc.v9i3.21834 EN Ali Valinejadi Khomein University of Medical Sciences, Khomein, Iran 0000-0003-4414-2732 Maryam Hassanzad Pediatric Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran 0000-0001-7164-0599 Nastaran Sharifi Psychology Department, Roudhen Branch, Islamic Azad University, Roudhen, Iran 0009-0000-0068-4770 Abdolhossein Kalantari Department of Sociology, Faculty of Social sciences, University of Tehran, Tehran, Iran 0000-0002-7518-6204 Binazir Jalali Department of Psychology, Faculty of Psychology and Education, University of Tehran, Tehran, Iran 0000-0001-7218-6244 Leila Mohammadpour-Belvirdy Khomein University of Medical Sciences, Khomein, Iran 0009-0008-2927-9769 Ali Akbar Velayati Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran 0000-0001-9398-5838 Journal Article 2025 05 05 <strong>Background:</strong> Cystic Fibrosis (CF) is a chronic disease frequently associated with psychological issues like anxiety and depression, often influenced by socioeconomic status (SES) and perceived social support (PSS). This study investigated the relationship between PSS, SES, and anxiety and depression levels in CF patients.<br><strong>Methods:</strong> A cross-sectional study involving 100 CF patients at the National Research Institute of Tuberculosis and Lung Disease (NRITLD) in Tehran, Iran (2024) utilized self-administered questionnaires for SES, Beck Anxiety Inventory (BAI), Beck Depression Inventory-II (BDI-II), and Multidimensional Perceived Social Support Scale (MPSS). Data were collected in person or online. Statistical analyses included descriptive statistics, Pearson correlations, and simultaneous multiple regression (α=0.05).<br><strong>Results:</strong> Simultaneous regression revealed PSS as a positive predictor of anxiety (B=0.551, β=0.309, p=0.047), and SES as a negative predictor (B=–0.532, β=–0.570, p=0.001), explaining 23.2% of anxiety variance (R=0.482, R²=0.232; F(2,97)=7.11, p=0.002). The depression model was also significant (R=0.594, R²=0.301; F(2,97)=10.13, p<0.001), with SES being a significant negative predictor (B=–0.705, β=–0.496, p=0.001), while PSS had a non-significant negative effect (B=–0.242, β=–0.089, p=0.540). Durbin–Watson statistics were 1.457 for anxiety and 0.985 for depression. Both anxiety and depression scores negatively correlated with PSS (r=–0.496, p≤0.05).<br><strong>Conclusion:</strong> PSS and SES are significantly associated with anxiety and depression in CF patients. Enhancing social support and addressing socioeconomic disparities could improve psychological well-being. Early screening and targeted interventions are recommended for managing mental health in this population. https://www.jimc.ir/article_245110_07eb40bc267f4874a6ea632012790a95.pdf