Parvovirus B19 Seropositivity and Its Laboratory and Clinical Effects in PICU Admitted Children at Mofid Children Hospital

Document Type: Original article

Authors

1 Pediatric Infections Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Mofid Children Hospital, Shahid Beheshti University of Medical Sciences Tehran, Iran

3 Alborzi Clinical Microbiology Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: Acute parvovirus infection may cause different complications and comorbidity in Pediatric Intensive Care Unit (PICU) patients. This study was conducted to investigate the effect of parvovirus infection on death, Hb, WBC count, and liver function tests in patients admitted to Mofid Children Hospital PICU from September 2015 to September 2016.
Methods: 66 children admitted to Mofid Children Hospital PICU were selected. Data on age, sex, underlying disease, anti-parvovirus IgG and IgM antibody, death, Hb, WBC count, AST, and ALT were gathered by questionnaire and data analysis was performed by the SPSS 21.
Results: Age range of children was 1-156 [Mean: 36.5(±41.3 SD)] months. Underlying diseases were gastrointestinal disease (13 cases), respiratory tract illnesses (14 cases), urinary tract diseases (6 cases), nervous system diseases (3 cases), hematological and oncological diseases (7 cases) and other diseases (3 cases). Quantitative results on IgG and IgM were analyzed. IgG and IgM were not significantly associated with Hb and WBC count. ALT over 12.5 IU was more significant in IgM positive cases and AST over 67 IU in IgG positive cases. IgM positivity was significantly associated with death (p<0.05).
Conclusion: Parvovirus serologic antibody can be an important measure in PICU patients because it can be associated with anemia, neutropenia, and LFT tests.

Keywords


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