Complications and hospital outcome of methanol toxicity in patients admitted in a northwest toxicology referral hospital of Iran

Document Type : Original article


1 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

2 Chronic kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

3 Department of Internal Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

4 Internal Medicine Department, Faculty of Medicine,Tabriz University of medical sciences ,Tabriz,Iran


Introduction: There has been multiple methanol poisoning outbreaks in Iran throughout the years thus understanding patient’s socioeconomic status, the type of alcohol they consumed or the reason behind their alcohol consumption will help us to establish ways to prevent these incidences from happening. The aim of this investigation is assessing the prognosis and complications of methanol intoxication.

Methods: This cross-sectional study was carried out on patients in Tabriz Sina hospital during 5 months. The data of the investigated patients was entered into SPSS26. Chi-Square and Logistic Regression tests were used in this analysis.

Results: From the 184 patients, 77.72% (143) recovered completely, 14.67% (27) recovered with permanent complications, and 7.61% (14) died. The most significant predictors of mortality were an increase in levels of Basal excess and creatinine and decrease in respiratory rate, systolic blood pressure and mean arterial pressure on admission and occurrence of arrhythmia. Visual symptoms on admission had protective effects against morbidity and mortality.

Conclusion: According to this study, poor outcome was associated with respiratory rate, systolic blood pressure, mean arterial pressure, levels of Basal excess and creatinine, and occurrence of arrhythmia, thus the clinician should evaluate the severity of methanol intoxication based on the history, lab results, vital signs and clinical symptoms in order to minimize morbidity and mortality.


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